Wholesale Wholesale Indole-3-Acetic Acid - China M-chlorodiphenylamine Manufacture Supplier – Longo Manufacturer and Supplier

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Wholesale Indole-3-Acetic Acid - China M-chlorodiphenylamine Manufacture Supplier – Longo Detail:

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Molecular formula: C12H10ClN

Molecular weight: 203.67

EINECS No.: 202-922-0

Related categories:Organic Chemistry;Aromatics

Mol file: 101-17-7.mol

Melting point: 112°C (Solv:methanol(67-56-1))

Boiling point: 340°C

Density: 1,21g/cm3

Refractive index: 1.6513 (estimate)

Storage conditions: 2-8°C

Solubility: Chloroform (Slightly), MethChemicalbookanol (Slightly)

Acidity coefficient: (pKa)-0.20±0.30(Predicted)

Form: Oil
Color: Pale Yellow to Yellow

CAS database: 101-17-7 (CASDataBaseReference)

Biological activity: 3-Chlorodiphenylamine is a high-affinity cardiac Ca2+ sensitizer (Ca2+sensitizer). 3-Chlorodiphenylamine is based on the diphenylamine structure and can bind to the N-terminal domain of cardiac troponin C (cTnC) (Kd=6µM). 3-Chlorodiphenylamine, due to its small molecular size, can serve as an excellent starting scaffold for the development of stronger Ca2+ sensitizing compounds for the study of systolic heart failure.

Target Kd: 6µM(N-domainofcardiactroponinC(cTnC))Kd:10µM(cNTnC–cSpchimera)

Chemical Properties: Liquid. Boiling point: 335-336 ℃ (96.3kPa), relative density 1.200, refractive index 1.6513. Soluble in ethanol, benzene, acetic acid and ether.

Uses: m-chlorodiphenylamine is an organic intermediate of diphenylamine, which is used to produce the drug chlorpromazine.
production methods : by the condensation of o-chlorobenzoic acid and m-chloroaniline, and then decarboxylated with iron powder.

Hazard category code: 20/21/22

Safety Instructions: 28-36/37

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