Products
One of Hottest for Pharmaceutical Corporation - Tert-butyl 1-piperazinecarboxylate – Longo Detail:
Structural Formula
Physical Properties
Appearance: White or light yellow crystal
Density: 1.030±0.06 g/cm3(Predicted)
Melting point: 43-47 °C(lit.)
Boiling point: 98-100
Flash point: >230 °F
Safety Data
Belongs to the dangerous goods
Customs code：2933990099
Export Tax Refund Rate(%)：11%
Application
In modern chemical pharmaceuticals, 1-tert-butoxycarbonyl piperazine plays a very important role because it is an important basic chemical raw material for many cough suppressants, anti-allergic drugs, antipsychotic drugs, antibacterial drugs, various pesticides, etc. Due to its wide range of uses and increasing demand, it accounts for a high proportion of the cost of various drugs, so reducing the industrialization cost of 1-tert-butoxycarbonyl piperazine has a very important industrialization value and economic value.
Uses:1-Boc piperazine is a useful Chemicalbook organic synthetic compound.
Applications:N-Boc-piperazine can be used to prepare the downstream product 1-[5-(trifluoromethyl)-2-pyridinyl]piperazine.
Synthesis method:The current synthesis of 1-tert-butoxycarbonyl piperazine method is mainly used anhydrous piperazine drop plus di-tert-butyl dicarbonate selective reaction to protect the nitrogen at one end of the piperazine, so that the other end of the amino group to react with another group, such a reaction method, both ends of the piperazine will be connected to di-tert-butyl dicarbonate, the purification must be washed with a large amount of water.
Operation disposal and storage
Precautions for safe handling
Avoid contact with skin and eyes. Prevent dust and aerosol generation.
Provide suitable exhaust ventilation in areas where dust is generated.
Conditions for safe storage, including any incompatibilities
Store in a cool place. Keep containers tightly closed and store in a dry and ventilated place.
Moisture-absorbing aerated storage Sensitive to carbon dioxide. Operate under inert gas. Protect from moisture.
Product detail pictures:
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