When citrulline is still an amino acid, because it is not encoded for DNA, it will not be embedded in proteins in protein biosynthesis, but some proteins still contain citrulline. These citrullines are produced by peptide arginine iminase (PAD), which converts arginine to citrulline during melonization. Generally, proteins containing citrulline include human myelin basic protein (MBP), polykeratin microfilament and some histones. For example, cellulose and vimentin can be ammoniated from cell death and tissue inflammation.
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1.Wan Xueshan, liuwenge, yanzhihong, etc Changes in contents of lycopene, citrulline, VC and other functional substances during watermelon fruit development. VIP, 2011
2.Liu Juan, Lu Xinxin, Meng Hui Research Progress on pharmacological effects and production methods of citrulline. CNKI; Wanfang, 2011
3.Huang Jing, Lin Hua, Wang Yongxin, Yao di Significance of combined detection of anti cyclic citrullinated peptide antibody, anti keratin antibody, anti perinuclear factor antibody and rheumatoid factor in the diagnosis of elderly rheumatoid arthritis. CNKI, 2010